MolNFT v1 · #319443 · protein

AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 6 (Q13882)

Q13882: “AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 6 (Q13882)”. 4 pockets (best druggability 0.72). MolNFT v1 #319443 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q13882
Type: protein
Length: 451 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x93f7e5ac43dcB2b93e5c93f453853F747a7d35AB
Molecule: Protein-tyrosine kinase 6
UniProt: Q13882
Pockets: 4 · best druggability 0.72

Structure

1 distinct chain · 29% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-tyrosine kinase 6	protein	451	29% helix, 25% strand	Q13882

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	950	0.72	0.76	63	empty
2	388	0.68	0.81	44	empty
3	88	0.51	0.84	21	empty
4	52	0.26	0.73	16	empty

Compared structures

5D7V · Crystal structure of PTK6 kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.53
5D7V · Crystal structure of PTK6 kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.53
5H2U · Crystal structure of PTK6 Kinase Domain complexed with Dasatinib · an experimental structure of the same protein · chain A against A, TM-score 0.53
5H2U · Crystal structure of PTK6 kinase domain complexed with dasatinib · an experimental structure of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13882
Elsewhere: UniProt Q13882 · AlphaFold DB Q13882

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