UniProt Q13882
Protein-tyrosine kinase 6 (Q13882)
Protein-tyrosine kinase 6 (UniProt Q13882), EC 2.7.10.2: 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13882
- Protein
- Protein-tyrosine kinase 6
- EC
- 2.7.10.2
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 21 · 4 records with a druggable one
Structures
17 records of Q13882 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RJA | Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain | solution nmr | A | — | — |
| 1RJA | Solution structure and backbone dynamics of the nonreceptor tyrosine kinase PTK6/BRK SH2 domain | solution nmr | A | — | — |
| 2KGT | Solution structure of SH3 domain of PTK6 | solution nmr | A | — | — |
| 2KGT | Solution structure of SH3 domain of PTK6 | solution nmr | A | — | — |
| 5D7V | Crystal structure of PTK6 kinase domain | x-ray diffraction | A, B, C, D | PO4 | 10 (best 0.69) |
| 5D7V | Crystal structure of PTK6 kinase domain | x-ray diffraction | A, B, C, D | — | — |
| 5DA3 | Crystal structure of PTK6 Kinase domain with inhibitor | x-ray diffraction | A | 58V | — |
| 5DA3 | Crystal structure of PTK6 kinase domain with inhibitor | x-ray diffraction | A | — | — |
| 5H2U | Crystal structure of PTK6 Kinase Domain complexed with Dasatinib | x-ray diffraction | A, B, C, D | 1N1 | — |
| 5H2U | Crystal structure of PTK6 kinase domain complexed with dasatinib | x-ray diffraction | A, B, C, D | — | — |
| 6CZ2 | Structure of the PTK6 kinase domain | x-ray diffraction | A | — | — |
| 6CZ2 | Structure of the PTK6 kinase domain | x-ray diffraction | A | — | — |
| 6CZ3 | Structure of the PTK6 kinase domain bound to a type I inhibitor… | x-ray diffraction | A | FLJ, K | 3 (best 0.69) |
| 6CZ3 | Structure of the PTK6 kinase domain bound to a type I inhibitor (3… | x-ray diffraction | A | FLJ, K | — |
| 6CZ4 | Structure of the PTK6 kinase domain bound to a type II inhibitor… | x-ray diffraction | A | FKY | 4 (best 0.80) |
| 6CZ4 | Structure of the PTK6 kinase domain bound to a type II inhibitor 2… | x-ray diffraction | A | FKY | — |
| Q13882 | AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 6 (Q13882) | predicted | A | — | 4 (best 0.72) |
Ligands
- FKY · 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy) phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide · in 2 records
- FLJ · (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone · in 2 records
- K · Potassium ion · in 2 records
- 1N1 · N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide · in 1 record
- 58V · (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 6CZ4 chain A against the predicted model Q13882: TM-score 0.90, RMSD 2.46 Å
- 6CZ4 chain A against the predicted model Q13882: TM-score 0.90, RMSD 2.46 Å
- 5H2U chain B against the predicted model Q13882: TM-score 0.89, RMSD 2.44 Å
- 5H2U chain B against the predicted model Q13882: TM-score 0.89, RMSD 2.44 Å
- 5D7V chain B against the predicted model Q13882: TM-score 0.88, RMSD 2.38 Å
- 5D7V chain B against the predicted model Q13882: TM-score 0.88, RMSD 2.38 Å
- 5D7V chain C against the predicted model Q13882: TM-score 0.88, RMSD 2.34 Å
- 5H2U chain C against the predicted model Q13882: TM-score 0.88, RMSD 2.54 Å
- 5H2U chain C against the predicted model Q13882: TM-score 0.88, RMSD 2.54 Å
- 5DA3 chain A against the predicted model Q13882: TM-score 0.88, RMSD 2.35 Å
Elsewhere
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