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Ligand · FKY

FKY · 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy) phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide

FKY, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy) phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide (C24 H23 F4 N5 O4, 521.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB…

Component
FKY
Formula
C24 H23 F4 N5 O4
Class
ligand
Structures
2
PDB entries
2

Binding sites

FKY in 2 structures; the first of them:

  • 6CZ4 · Structure of the PTK6 kinase domain bound to a type II inhibitor 2… · FKY A9001 · binds LEU197, VAL205, ALA217, MET239, LEU242, ILE247, LEU248, THR264 and 15 more
  • 6DKB · Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 10B. · FKY A4000 · binds LEU516, VAL524, ALA542, LEU564, LEU567, VAL573, PHE589, GLU590 and 12 more

Residues it binds most

LEU 2, GLY 2, PHE 2, VAL 2, ALA 2, MET 2, ASP 2, GLU 2, HIS 2, ILE 2 (residue and the binding sites it lines).

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