MolNFT v1 · #145813 · protein

Structure of the PTK6 kinase domain

6CZ2 · Protein-tyrosine kinase 6: “Structure of the PTK6 kinase domain”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #145813 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CZ2
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-tyrosine kinase 6
EC: 2.7.10.2
UniProt: Q13882
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-tyrosine kinase 6 (EC 2.7.10.2)	protein	262	40% helix, 18% strand	Q13882

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	277	0.70	0.85	39	empty
2	95	0.43	0.78	17	empty
3	66	0.31	0.74	13	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

6CZ2 · Structure of the PTK6 kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q13882 · AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 6 (Q13882) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13882
Elsewhere: RCSB PDB 6CZ2 · PDBe 6CZ2 · UniProt Q13882

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