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Crystal structure of gltph fast mutant - R276S/M395R

Analyse Crystal structure of gltph fast mutant - R276S/M395R in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CTF
Type: protein
Length: 1,233 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate transporter homolog
UniProt: O59010
Ligands: ASP, NA
Pockets: 18 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Glutamate transporter homolog	protein	411	75% helix, 0% strand	O59010

Ligands and binding sites

ASP · Aspartic acid · ligand · 3 copies · chains A, B, C
NA · Sodium ion · metal · 6 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	762	0.87	0.90	48	empty
2	684	0.69	0.77	89	empty
3	564	0.65	0.76	73	empty
4	393	0.64	0.78	52	empty
5	387	0.62	0.77	45	empty

Interfaces

3 interfaces between chains.

A–C · 1095 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1059 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1054 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6CTF · Crystal structure of GltPh fast mutant - R276S/M395R · the same entry in another collection · chain B against B, TM-score 1.00
O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain C against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59010
Elsewhere: RCSB PDB 6CTF · PDBe 6CTF · UniProt O59010

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