Research workbench
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
Analyse Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CM4
- Type
- protein
- Length
- 423 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- D(2) dopamine receptor, endolysin chimera
- EC
- 3.2.1.17
- UniProt
- P14416, D9IEF7
- Ligands
- OLA, 8NU
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 77% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | D(2) dopamine receptor, endolysin chimera (EC 3.2.1.17) | protein | 423 | 77% helix, 4% strand | P14416, D9IEF7 |
Ligands and binding sites
- OLA · Oleic acid · ligand · 3 copies · chains A
- 8NU · 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one · ligand · chains A
- PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.69 | 0.83 | 32 | 8NU |
| 2 | 247 | 0.55 | 0.77 | 33 | empty |
| 3 | 58 | 0.47 | 0.84 | 14 | OLA |
| 4 | 62 | 0.30 | 0.74 | 14 | PEG |
| 5 | 65 | 0.27 | 0.72 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6CM4 · Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone · the same entry in another collection · chain A against A, TM-score 1.00
- P14416 · AlphaFold monomer V2.0 prediction for D(2) dopamine receptor (P14416) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14416
- Every structure of UniProt D9IEF7
- Elsewhere: RCSB PDB 6CM4 · PDBe 6CM4 · UniProt P14416 · UniProt D9IEF7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.