UniProt P14416
D(2) dopamine receptor, endolysin chimera (P14416)
D(2) dopamine receptor, endolysin chimera (UniProt P14416), EC 3.2.1.17: 11 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P14416
- Protein
- D(2) dopamine receptor, endolysin chimera
- EC
- 3.2.1.17
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 23 · 5 records with a druggable one
Structures
12 records of P14416 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AER | Neuronal calcium sensor-1 (ncs-1)FROM rattus norvegicus complex with D2 dopamine receptor peptide… | x-ray diffraction | B, C | — | — |
| 6CM4 | Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone | x-ray diffraction | A | 8NU, OLA | 5 (best 0.69) |
| 6CM4 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone | x-ray diffraction | A | 8NU, OLA | — |
| 6LUQ | Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands | x-ray diffraction | A | GMJ, OLA | 6 (best 0.69) |
| 6LUQ | Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands | x-ray diffraction | A | GMJ, OLA | — |
| 6VMS | Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane | electron microscopy | R | 08Y | 4 (best 0.78) |
| 6VMS | Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane | electron microscopy | R | 08Y | — |
| 7DFP | Human dopamine D2 receptor in complex with spiperone | x-ray diffraction | A | SIP | 5 (best 0.85) |
| 7DFP | Human dopamine D2 receptor in complex with spiperone | x-ray diffraction | A | SIP | — |
| 7JVR | Cryo-EM structure of bromocriptine-bound dopamine receptor 2 in complex with gi protein | electron microscopy | R | 08Y | — |
| 8IRS | Dopamine Receptor D2R-Gi-Rotigotine complex | electron microscopy | R | R5F | 3 (best 0.78) |
| P14416 | AlphaFold monomer V2.0 prediction for D(2) dopamine receptor (P14416) | predicted | A | — | — |
Ligands
- OLA · Oleic acid · in 4 records
- 08Y · bromoergocryptine · in 3 records
- 8NU · 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one · in 2 records
- GMJ · 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one · in 2 records
- SIP · 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one · in 2 records
- R5F · Rotigotine · in 1 record
Experiment against prediction
- 8IRS chain R against the predicted model P14416: TM-score 0.93, RMSD 2.04 Å
- 7JVR chain R against the predicted model P14416: TM-score 0.91, RMSD 2.22 Å
- 6VMS chain R against the predicted model P14416: TM-score 0.88, RMSD 2.78 Å
- 6VMS chain R against the predicted model P14416: TM-score 0.88, RMSD 2.78 Å
- 7DFP chain A against the predicted model P14416: TM-score 0.78, RMSD 3.06 Å
- 7DFP chain A against the predicted model P14416: TM-score 0.78, RMSD 3.06 Å
- 5AER chain B against the predicted model P14416: TM-score 0.74, RMSD 1.00 Å
- 5AER chain C against the predicted model P14416: TM-score 0.71, RMSD 0.84 Å
- 6LUQ chain A against the predicted model P14416: TM-score 0.64, RMSD 3.41 Å
- 6LUQ chain A against the predicted model P14416: TM-score 0.64, RMSD 3.41 Å
Elsewhere
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