Research workbench
Structure of the sthk cyclic nucleotide-gated potassium channel in complex with camp
Analyse Structure of the sthk cyclic nucleotide-gated potassium channel in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CJU
- Type
- protein
- Length
- 1,560 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sthk cyclic nucleotide-gated potassium channel
- UniProt
- G0GA88
- Ligands
- PGW, CMP
- Pockets
- 20 · best druggability 0.72
Structure
electron microscopy · 1 distinct chain · 56% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Sthk cyclic nucleotide-gated potassium channel | protein | 390 | 56% helix, 7% strand | G0GA88 |
Ligands and binding sites
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 32 copies · chains A, B, C, D
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.72 | 0.80 | 48 | empty |
| 2 | 937 | 0.71 | 0.76 | 73 | empty |
| 3 | 469 | 0.70 | 0.81 | 38 | empty |
| 4 | 515 | 0.69 | 0.79 | 52 | empty |
| 5 | 445 | 0.68 | 0.80 | 39 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2647 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 2645 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2644 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2643 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 50 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6CJU · Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0GA88
- Elsewhere: RCSB PDB 6CJU · PDBe 6CJU · UniProt G0GA88
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