Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and lividomycin moieties

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 4 copies · chains A, B, C, D
• LIV · (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3, 5-diamino-2-((2S,3R,5S,6R)-3-amino-5-hydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-6-hydroxycyclohexyloxy)-4-hydroxy-2-(hydroxymethyl)-tetrahydrofuran-3-yloxy)-4-hydroxy-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol · ligand · chains D
• MG · Magnesium ion · metal · 9 copies · chains A, B, C, D
• CL · Chloride ion · ion · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6CEY · Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and… · the same entry in another collection · chain D against D, TM-score 1.00
• P0A0C1 · AlphaFold monomer V2.0 prediction for bifunctional AAC/APH (P0A0C1) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0A0C1
• Elsewhere: RCSB PDB 6CEY · PDBe 6CEY · UniProt P0A0C1