UniProt P0A0C1
Bifunctional AAC/APH (P0A0C1)
Bifunctional AAC/APH (UniProt P0A0C1), EC 2.3.1.-, 2.7.1.-: 25 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P0A0C1
- Protein
- Bifunctional AAC/APH
- EC
- 2.3.1.-, 2.7.1.-, 2.7.1.190
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 21 · 2 records with a druggable one
Structures
26 records of P0A0C1 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ORK | Crystal Structure of the Phosphotransferase Domain of the Bifunctional Aminoglycoside Resistance… | x-ray diffraction | A, B, C, D | — | — |
| 4ORK | Crystal structure of the phosphotransferase domain of the bifunctional aminoglycoside resistance… | x-ray diffraction | A, B, C, D | — | — |
| 5BYL | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPCP… | x-ray diffraction | A, B, C, D | GCP, MG, CL | 10 (best 0.74) |
| 5BYL | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppcp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQA | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppnp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQB | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppnp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQC | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppnp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQD | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP… | x-ray diffraction | A, B, C, D | GNP, RIO, MG, CL | — |
| 5IQD | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppnp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQE | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP… | x-ray diffraction | A, B, C, D | GNP, NMY, MG | — |
| 5IQE | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with gmppnp… | x-ray diffraction | A, B, C, D | — | — |
| 5IQF | Aminoglycoside phosphotransferase (2'')-ia (ctd of APH(6')- IE/APH(2'')-ia) in complex with GDP and… | x-ray diffraction | A, B, C, D | — | — |
| 5IQG | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GDP… | x-ray diffraction | A, B, C, D | GDP, 51G, MG, CL | — |
| 5IQG | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) in complex with GDP… | x-ray diffraction | A, B, C, D | — | — |
| 5IQH | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) S214A mutant in complex… | x-ray diffraction | A, B, C, D | GNP, MG, CL | — |
| 5IQH | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) S214A mutant in complex… | x-ray diffraction | A, B, C, D | — | — |
| 5IQI | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) Y237F mutant in complex… | x-ray diffraction | A, B, C, D | GNP, MG, CL | — |
| 5IQI | Aminoglycoside phosphotransferase (2'')-ia (ctd of AAC(6')- IE/APH(2'')-ia) Y237F mutant in complex… | x-ray diffraction | A, B, C, D | — | — |
| 6C5U | Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and ribostamycin… | x-ray diffraction | A, B, C, D | GNP, RIO, MG, CL | — |
| 6CAV | Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and dibekacin | x-ray diffraction | A, B, C, D | GNP, MG, CL, 84D | — |
| 6CEY | Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and lividomycin… | x-ray diffraction | A, B, C, D | GNP, MG, CL, LIV | — |
| 6CGD | Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and amikacin | x-ray diffraction | A, B, C, D | GNP, AKN, MG, CL | — |
| 6CGG | Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Arbekacin | x-ray diffraction | A, B, C, D | GNP, MG, CL, 84G | 11 (best 0.76) |
| 6CGG | Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and arbekacin | x-ray diffraction | A, B, C, D | GNP, MG, CL, 84G | — |
| 6CH4 | Aminoglycoside phosphotransferase (2'')-ia S376N mutant in complex with gmppnp and magnesium | x-ray diffraction | A, B, C, D | GNP, MG, CL | — |
| P0A0C1 | AlphaFold monomer V2.0 prediction for bifunctional AAC/APH (P0A0C1) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 13 records
- CL · Chloride ion · in 12 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 11 records
- 84G · Arbekacin · in 2 records
- RIO · Ribostamycin · in 2 records
- 51G · gentamicin C1 · in 1 record
- 84D · Dibekacin · in 1 record
- AKN · (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide · in 1 record
- GCP · Phosphomethylphosphonic acid guanylate ester · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- LIV · (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3, 5-diamino-2-((2S,3R,5S,6R)-3-amino-5-hydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-6-hydroxycyclohexyloxy)-4-hydroxy-2-(hydroxymethyl)-tetrahydrofuran-3-yloxy)-4-hydroxy-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol · in 1 record
- NMY · Neomycin · in 1 record
Experiment against prediction
- 6C5U chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.39 Å
- 5IQG chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.41 Å
- 5IQG chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.41 Å
- 5IQE chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.44 Å
- 5IQE chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.44 Å
- 6CEY chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.44 Å
- 5IQB chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.44 Å
- 6CEY chain A against the predicted model P0A0C1: TM-score 1.00, RMSD 0.43 Å
- 5IQH chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.45 Å
- 5IQH chain B against the predicted model P0A0C1: TM-score 1.00, RMSD 0.45 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.