AKN · (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide

Binding sites

AKN in 4 structures; the first of them:

• 8SYL · Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA… · AKN a3099 · binds C1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1492 and 8 more
• 6CGD · Aminoglycoside phosphotransferase (2'')-ia in complex with gmppnp, magnesium, and amikacin · AKN A600 · binds SER210, GLY211, TYR212, ASP374, ASP396, TYR408, GLU411, VAL444 and 3 more
• 6VTA · Aminoglycoside N-2'-acetyltransferase-ia [AAC(2')-ia] in complex with amikacin and… · AKN A302 · binds PHE29, ASP32, PHE33, ASP37, GLU79, ALA80, SER114, ALA115 and 5 more
• 6YPU · Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body · AKN 41607 · binds C1401, G1402, C1404, A1405, G1488, A1489, A1490, G1491 and 4 more

Residues it binds most

G 3, GLU 4, C 3, ASP 4, A 3, SER 4, U 3, TYR 2, ALA 2, PHE 2 (residue and the binding sites it lines).

Found with

• MG · Magnesium ion
• ACO · Acetyl coenzyme *A
• GNP · Phosphoaminophosphonic acid-guanylate ester
• PHE · Phenylalanine
• ZN · Zinc ion
• CL · Chloride ion