Research workbench
Insulin receptor ectodomain in complex with one insulin molecule
Analyse Insulin receptor ectodomain in complex with one insulin molecule in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CE7
- Type
- protein
- Length
- 1,268 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin a chain; Insulin B chain; Insulin receptor subunit alpha
- EC
- 2.7.10.1
- UniProt
- P06213, P01308, P01318
- Pockets
- 14 · best druggability 0.89
Structure
electron microscopy · 5 distinct chains · 11% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Insulin receptor (EC 2.7.10.1) | protein | 659 | 8% helix, 28% strand | P06213 |
| A | Insulin receptor (EC 2.7.10.1) | protein | 528 | 8% helix, 27% strand | P06213 |
| N | Insulin a chain | protein | 21 | 62% helix, 0% strand | P01308 |
| O | Insulin B chain | protein | 30 | 33% helix, 0% strand | P01318 |
| P | Insulin receptor subunit alpha (EC 2.7.10.1) | protein | 30 | 73% helix, 0% strand | P06213 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1100 | 0.89 | 0.90 | 147 | empty |
| 2 | 639 | 0.84 | 0.88 | 74 | empty |
| 3 | 247 | 0.83 | 0.94 | 41 | empty |
| 4 | 550 | 0.69 | 0.78 | 58 | empty |
| 5 | 312 | 0.57 | 0.77 | 39 | empty |
Interfaces
9 interfaces between chains.
- A–P · 654 Ų buried · 7 hydrogen bonds · protein-protein
- N–O · 629 Ų buried · 8 hydrogen bonds · protein-protein
- A–O · 494 Ų buried · 4 hydrogen bonds · protein-protein
- N–P · 356 Ų buried · 11 hydrogen bonds · protein-protein
- O–P · 275 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 27 disulfide (disulfide).
Compared structures
- 6CE7 · Insulin Receptor ectodomain in complex with one insulin molecule · the same entry in another collection · chain P against P, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain B against A, TM-score 0.69
- P01318 · AlphaFold monomer V2.0 prediction for insulin (P01318) · a predicted model of the same protein · chain O against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Every structure of UniProt P01318
- Elsewhere: RCSB PDB 6CE7 · PDBe 6CE7 · UniProt P06213 · UniProt P01308 · UniProt P01318
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