Research workbench
Chimeric pol kappa rir REV1 C-terminal domain in complex with JHRE06
Analyse Chimeric pol kappa rir REV1 C-terminal domain in complex with JHRE06 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C8C
- Type
- protein
- Length
- 233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimeric protein of the pol kappa rir helix and the REV1 C- terminal domain
- EC
- 2.7.7.7, 2.7.7.-
- UniProt
- Q9QUG2, Q920Q2
- Ligands
- EQ7
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimeric protein of the pol kappa rir helix and the REV1 C- terminal domain (EC 2.7.7.7, 2.7.7.-) | protein | 119 | 63% helix, 4% strand | Q9QUG2, Q920Q2 |
| B | Chimeric protein of the pol kappa rir helix and the REV1 C- terminal domain (EC 2.7.7.7, 2.7.7.-) | protein | 114 | 68% helix, 4% strand | Q9QUG2, Q920Q2 |
Ligands and binding sites
- EQ7 · 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.70 | 0.84 | 27 | EQ7 |
Interfaces
1 interface between chains.
- A–B · 612 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6C8C · Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06 · the same entry in another collection · chain A against A, TM-score 1.00
- Q920Q2 · AlphaFold monomer V2.0 prediction for DNA repair protein REV1 (Q920Q2) · a predicted model of the same protein · chain B against A, TM-score 0.82
- Q9QUG2 · AlphaFold monomer V2.0 prediction for DNA polymerase kappa (Q9QUG2) · a predicted model of the same protein · chain A against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QUG2
- Every structure of UniProt Q920Q2
- Elsewhere: RCSB PDB 6C8C · PDBe 6C8C · UniProt Q9QUG2 · UniProt Q920Q2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.