Research workbench
IGCAM3 of human MLCK1
Analyse IGCAM3 of human MLCK1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C6M
- Type
- protein
- Length
- 284 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin light chain kinase, smooth muscle
- EC
- 2.7.11.18
- UniProt
- Q15746
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Myosin light chain kinase, smooth muscle (EC 2.7.11.18) | protein | 95 | 3% helix, 58% strand | Q15746 |
| B | Myosin light chain kinase, smooth muscle (EC 2.7.11.18) | protein | 94 | 3% helix, 61% strand | Q15746 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.44 | 0.76 | 22 | empty |
| 2 | 91 | 0.39 | 0.77 | 28 | empty |
| 3 | 120 | 0.38 | 0.74 | 22 | empty |
| 4 | 110 | 0.36 | 0.74 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 494 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 320 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15746
- Elsewhere: RCSB PDB 6C6M · PDBe 6C6M · UniProt Q15746
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