MolNFT v1 · #255474 · protein
AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (Q15746)
Q15746: “AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (Q15746)”. 13 pockets (best druggability 0.78). MolNFT v1 #255474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q15746
- Type
- protein
- Length
- 1,914 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xF8cD1d8d93E9783063700De244A6e3cf6A195579
- Molecule
- Myosin light chain kinase, smooth muscle
- UniProt
- Q15746
- Pockets
- 13 · best druggability 0.78
Structure
1 distinct chain · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin light chain kinase, smooth muscle | protein | 1914 | 11% helix, 33% strand | Q15746 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.78 | 0.80 | 79 | empty |
| 2 | 525 | 0.63 | 0.76 | 53 | empty |
| 3 | 208 | 0.56 | 0.79 | 30 | empty |
| 4 | 172 | 0.48 | 0.76 | 27 | empty |
| 5 | 77 | 0.44 | 0.81 | 13 | empty |
Compared structures
- 2CQV · Solution structure of the eighth ig-like domain of human myosin light chain kinase · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2CQV · Solution structure of the eighth Ig-like domain of human myosin light chain kinase · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2YR3 · Solution structure of the fourth Ig-like domain from myosin light chain kinase, smooth… · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2YR3 · Solution structure of the fourth ig-like domain from myosin light chain kinase, smooth… · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 6C6M · IGCAM3 of human MLCK1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 6C6M · IgCam3 of human MLCK1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 5JQA · CaM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5JQA · CAM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5JTH · Crystal structure of E67A calmodulin - CAM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15746
- Elsewhere: UniProt Q15746 · AlphaFold DB Q15746
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.