Research workbench
AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (Q15746)
Analyse AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q15746
- Type
- protein
- Length
- 1,914 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xF8cD1d8d93E9783063700De244A6e3cf6A195579
- Molecule
- Myosin light chain kinase, smooth muscle
- UniProt
- Q15746
- Pockets
- 13 · best druggability 0.78
Structure
1 distinct chain · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin light chain kinase, smooth muscle | protein | 1914 | 11% helix, 33% strand | Q15746 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.78 | 0.80 | 79 | empty |
| 2 | 525 | 0.63 | 0.76 | 53 | empty |
| 3 | 208 | 0.56 | 0.79 | 30 | empty |
| 4 | 172 | 0.48 | 0.76 | 27 | empty |
| 5 | 77 | 0.44 | 0.81 | 13 | empty |
Compared structures
- 2CQV · Solution structure of the eighth ig-like domain of human myosin light chain kinase · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2CQV · Solution structure of the eighth Ig-like domain of human myosin light chain kinase · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2YR3 · Solution structure of the fourth Ig-like domain from myosin light chain kinase, smooth… · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2YR3 · Solution structure of the fourth ig-like domain from myosin light chain kinase, smooth… · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 6C6M · IGCAM3 of human MLCK1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 6C6M · IgCam3 of human MLCK1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 5JQA · CaM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5JQA · CAM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5JTH · Crystal structure of E67A calmodulin - CAM:RM20 complex · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15746
- Elsewhere: UniProt Q15746 · AlphaFold DB Q15746
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