UniProt Q15746
Myosin light chain kinase, smooth muscle (Q15746)
Myosin light chain kinase, smooth muscle (UniProt Q15746), EC 2.7.11.18: 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q15746
- Protein
- Myosin light chain kinase, smooth muscle
- EC
- 2.7.11.18
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 3 records with a druggable one
Structures
13 records of Q15746 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CQV | Solution structure of the eighth Ig-like domain of human myosin light chain kinase | solution nmr | A | — | — |
| 2CQV | Solution structure of the eighth ig-like domain of human myosin light chain kinase | solution nmr | A | — | — |
| 2K0F | Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase | solution nmr | B | — | — |
| 2K0F | Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase | solution nmr | B | — | — |
| 2YR3 | Solution structure of the fourth Ig-like domain from myosin light chain kinase, smooth muscle | solution nmr | A | — | — |
| 2YR3 | Solution structure of the fourth ig-like domain from myosin light chain kinase, smooth muscle | solution nmr | A | — | — |
| 5JQA | CaM:RM20 complex | x-ray diffraction | B | — | 1 (best 0.36) |
| 5JQA | CAM:RM20 complex | x-ray diffraction | B | — | — |
| 5JTH | Crystal structure of E67A calmodulin - CaM:RM20 analog complex | x-ray diffraction | B | — | 1 (best 0.51) |
| 5JTH | Crystal structure of E67A calmodulin - CAM:RM20 complex | x-ray diffraction | B | NH2 | 1 (best 0.51) |
| 6C6M | IgCam3 of human MLCK1 | x-ray diffraction | A, B, C | — | 4 (best 0.44) |
| 6C6M | IGCAM3 of human MLCK1 | x-ray diffraction | A, B, C | — | — |
| Q15746 | AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (Q15746) | predicted | A | — | 13 (best 0.78) |
Ligands
- NH2 · Amino group · in 1 record
Experiment against prediction
- 6C6M chain B against the predicted model Q15746: TM-score 0.97, RMSD 0.65 Å
- 6C6M chain B against the predicted model Q15746: TM-score 0.97, RMSD 0.65 Å
- 6C6M chain A against the predicted model Q15746: TM-score 0.97, RMSD 0.67 Å
- 6C6M chain A against the predicted model Q15746: TM-score 0.97, RMSD 0.67 Å
- 6C6M chain C against the predicted model Q15746: TM-score 0.96, RMSD 0.74 Å
- 2YR3 chain A against the predicted model Q15746: TM-score 0.88, RMSD 1.58 Å
- 2YR3 chain A against the predicted model Q15746: TM-score 0.88, RMSD 1.58 Å
- 2CQV chain A against the predicted model Q15746: TM-score 0.82, RMSD 1.57 Å
- 2CQV chain A against the predicted model Q15746: TM-score 0.82, RMSD 1.57 Å
- 5JQA chain B against the predicted model Q15746: TM-score 0.63, RMSD 0.55 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.