Research workbench

Human ABCC6 NBD1 in apo state

Analyse Human ABCC6 NBD1 in apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6BZS
Type: protein
Length: 230 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug resistance-associated protein 6
UniProt: O95255
Ligands: SO4
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multidrug resistance-associated protein 6	protein	230	33% helix, 28% strand	O95255

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.50	0.83	20	empty
2	67	0.32	0.75	12	empty

Compared structures

6BZS · Human ABCC6 NBD1 in Apo state · the same entry in another collection · chain A against A, TM-score 1.00
O95255 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 6 (O95255) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95255
Elsewhere: RCSB PDB 6BZS · PDBe 6BZS · UniProt O95255

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