Research workbench
Human ATL1 mutant - R77A bound to GDP
Analyse Human ATL1 mutant - R77A bound to GDP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B9D
- Type
- protein
- Length
- 759 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Atlastin-1
- EC
- 3.6.5.-
- UniProt
- Q8WXF7
- Ligands
- GDP, MG
- Pockets
- 10 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Atlastin-1 (EC 3.6.5.-) | protein | 379 | 50% helix, 17% strand | Q8WXF7 |
| B | Atlastin-1 (EC 3.6.5.-) | protein | 380 | 52% helix, 18% strand | Q8WXF7 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- GOL · Glycerol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 436 | 0.61 | 0.76 | 49 | GOL |
| 2 | 168 | 0.49 | 0.77 | 23 | empty |
| 3 | 187 | 0.49 | 0.76 | 24 | GDP |
| 4 | 220 | 0.48 | 0.75 | 38 | GDP, MG |
| 5 | 138 | 0.45 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 518 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WXF7
- Elsewhere: RCSB PDB 6B9D · PDBe 6B9D · UniProt Q8WXF7
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