UniProt Q8WXF7
Atlastin-1 (Q8WXF7)
Atlastin-1 (UniProt Q8WXF7), EC 3.6.5.-: 28 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WXF7
- Protein
- Atlastin-1
- EC
- 3.6.5.-
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 37 · 5 records with a druggable one
Structures
29 records of Q8WXF7 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3Q5D | crystal structure of human Atlastin-1 (residues 1-447) bound to GDP, crystal form 1 | x-ray diffraction | A | — | — |
| 3Q5D | Crystal structure of human atlastin-1 (residues 1-447) bound to GDP, crystal form 1 | x-ray diffraction | A | — | — |
| 3Q5E | crystal structure of human Atlastin-1 (residues 1-447) bound to GDP, crystal form 2 | x-ray diffraction | A, C, E, G | — | — |
| 3Q5E | Crystal structure of human atlastin-1 (residues 1-447) bound to GDP, crystal form 2 | x-ray diffraction | A, C, E, G | — | — |
| 3QNU | Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, hexagonal form | x-ray diffraction | A | — | — |
| 3QNU | Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, hexagonal form | x-ray diffraction | A | — | — |
| 3QOF | Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, orthorhombic form | x-ray diffraction | A, B, C, D | — | — |
| 3QOF | Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, orthorhombic form | x-ray diffraction | A, B, C, D | — | — |
| 4IDN | Human atlastin-1 1-446, C-his6, GppNHp | x-ray diffraction | A, B | — | — |
| 4IDN | Human atlastin-1 1-446, C-HIS6, gppnhp | x-ray diffraction | A, B | — | — |
| 4IDO | human atlastin-1 1-446, C-his6, GDPAlF4- | x-ray diffraction | A, B | — | — |
| 4IDO | Human atlastin-1 1-446, C-HIS6, GDPALF4- | x-ray diffraction | A, B | — | — |
| 4IDP | human atlastin-1 1-446, N440T, GppNHp | x-ray diffraction | A, B, C, D | — | — |
| 4IDP | Human atlastin-1 1-446, N440T, gppnhp | x-ray diffraction | A, B, C, D | — | — |
| 4IDQ | human atlastin-1 1-446, N440T, GDPAlF4- | x-ray diffraction | A, B, C, D | — | — |
| 4IDQ | Human atlastin-1 1-446, N440T, GDPALF4- | x-ray diffraction | A, B, C, D | — | — |
| 6B9D | Human ATL1 mutant - R77A bound to GDP | x-ray diffraction | A, B | GDP, MG | 10 (best 0.61) |
| 6B9D | Human ATL1 mutant - R77A bound to GDP | x-ray diffraction | A, B | GDP, MG | — |
| 6B9E | Human ATL1 mutant - R77A / F151S bound to GDP | x-ray diffraction | A, B | GDP, MG, SO4 | 10 (best 0.58) |
| 6B9E | Human ATL1 mutant - R77A / F151S bound to GDP | x-ray diffraction | A, B | GDP, MG, SO4 | — |
| 6B9F | Human ATL1 mutant - F151S bound to GDPAlF4- | x-ray diffraction | A, B | MG, GDP, ALF | — |
| 6B9F | Human ATL1 mutant - F151S bound to GDPALF4- | x-ray diffraction | A, B | MG, GDP, ALF | — |
| 6B9G | human ATL1 GTPase domain bound to GDP | x-ray diffraction | B, C, D, A | GDP, MG | 4 (best 0.88) |
| 6B9G | Human ATL1 GTPase domain bound to GDP | x-ray diffraction | B, C, D, A | GDP, MG | — |
| 6XJN | Human atlastin-1 (residues 1-439) bound to GDP-Mg2+ exhibits an ordered amino terminus | x-ray diffraction | A | GDP, MG | 3 (best 0.52) |
| 6XJN | Human atlastin-1 (residues 1-439) bound to GDP-MG2+ exhibits an ordered amino terminus | x-ray diffraction | A | GDP, MG | — |
| 7OL3 | Human ATL1 N417ins (catalytic core) | x-ray diffraction | A, B | GDP, ALF, MG | 10 (best 0.82) |
| 7OL3 | Human ATL1 N417INS (catalytic core) | x-ray diffraction | A, B | GDP, ALF, MG | — |
| Q8WXF7 | AlphaFold monomer V2.0 prediction for atlastin-1 (Q8WXF7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6B9F chain A against the predicted model Q8WXF7: TM-score 1.00, RMSD 0.50 Å
- 6B9F chain A against the predicted model Q8WXF7: TM-score 1.00, RMSD 0.50 Å
- 4IDN chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.53 Å
- 4IDN chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.53 Å
- 4IDO chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.54 Å
- 4IDO chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.54 Å
- 7OL3 chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.74 Å
- 7OL3 chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.74 Å
- 4IDQ chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.96 Å
- 4IDQ chain A against the predicted model Q8WXF7: TM-score 0.99, RMSD 0.96 Å
Elsewhere
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