Research workbench
Crystal structure of the second SH3 domain of STAC3 (309-364)
Analyse Crystal structure of the second SH3 domain of STAC3 (309-364) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B29
- Type
- protein
- Length
- 230 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SH3 and cysteine-rich domain-containing protein 3
- UniProt
- Q96MF2
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | SH3 and cysteine-rich domain-containing protein 3 | protein | 57 | 11% helix, 51% strand | Q96MF2 |
| B | SH3 and cysteine-rich domain-containing protein 3 | protein | 59 | 10% helix, 42% strand | Q96MF2 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.47 | 0.75 | 30 | empty |
| 2 | 76 | 0.29 | 0.73 | 17 | empty |
| 3 | 51 | 0.26 | 0.74 | 15 | empty |
Interfaces
3 interfaces between chains.
- C–D · 510 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 480 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 14 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6B29 · Crystal structure of the second SH3 domain of STAC3 (309-364) · the same entry in another collection · chain A against A, TM-score 1.00
- Q96MF2 · AlphaFold monomer V2.0 prediction for SH3 and cysteine-rich domain- containing protein 3… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96MF2
- Elsewhere: RCSB PDB 6B29 · PDBe 6B29 · UniProt Q96MF2
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