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Crystal structure of apoptosis inducing factor (aif)

Analyse Crystal structure of apoptosis inducing factor (aif) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1M6I
Type: protein
Length: 459 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Programmed cell death protein 8
UniProt: O95831
Ligands: FAD
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Programmed cell death protein 8	protein	459	28% helix, 31% strand	O95831

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1001	0.82	0.83	94	FAD
2	53	0.32	0.77	15	empty
3	55	0.27	0.73	14	empty

Compared structures

1M6I · Crystal Structure of Apoptosis Inducing Factor (AIF) · the same entry in another collection · chain A against A, TM-score 1.00
O95831 · AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (O95831) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95831
Elsewhere: RCSB PDB 1M6I · PDBe 1M6I · UniProt O95831

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