Research workbench
Transglutaminase 2 mutant G224V in complex with GTP
Analyse Transglutaminase 2 mutant G224V in complex with GTP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A8P
- Type
- protein
- Length
- 2,027 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-glutamine gamma-glutamyltransferase 2
- EC
- 2.3.2.13
- UniProt
- P21980
- Ligands
- GTP
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) | protein | 681 | 16% helix, 42% strand | P21980 |
| B | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) | protein | 666 | 16% helix, 40% strand | P21980 |
| C | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) | protein | 680 | 16% helix, 41% strand | P21980 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1187 | 0.87 | 0.88 | 93 | empty |
| 2 | 745 | 0.75 | 0.80 | 86 | empty |
| 3 | 490 | 0.71 | 0.81 | 67 | empty |
| 4 | 180 | 0.69 | 0.88 | 39 | empty |
| 5 | 223 | 0.68 | 0.85 | 46 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1411 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 827 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6A8P · Transglutaminase 2 mutant G224V in complex with GTP · the same entry in another collection · chain A against A, TM-score 1.00
- P21980 · AlphaFold monomer V2.0 prediction for protein-glutamine gamma- glutamyltransferase 2… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21980
- Elsewhere: RCSB PDB 6A8P · PDBe 6A8P · UniProt P21980
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