UniProt P21980
Protein-glutamine gamma-glutamyltransferase 2 (P21980)
Protein-glutamine gamma-glutamyltransferase 2 (UniProt P21980), EC 2.3.1.-, 2.3.2.13: 22 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 51 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21980
- Protein
- Protein-glutamine gamma-glutamyltransferase 2
- EC
- 2.3.1.-, 2.3.2.13, 3.4.-.-, 3.5.1.44
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 51 · 5 records with a druggable one
Structures
23 records of P21980 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KV3 | Human tissue transglutaminase in GDP bound form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1KV3 | Human tissue transglutaminase in GDP bound form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2Q3Z | Transglutaminase 2 undergoes large conformational change upon activation | x-ray diffraction | A | — | — |
| 2Q3Z | Transglutaminase 2 undergoes large conformational change upon activation | x-ray diffraction | A | — | — |
| 3LY6 | Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate | x-ray diffraction | A, B, C | — | — |
| 3LY6 | Crystal structure of human transglutaminase 2 complex with adenosine 5' triphosphate | x-ray diffraction | A, B, C | — | — |
| 3S3J | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 3S3J | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 3S3P | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 3S3P | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 3S3S | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 3S3S | Transglutaminase 2 in complex with a novel inhibitor | x-ray diffraction | A | — | — |
| 4PYG | Transglutaminase2 complexed with GTP | x-ray diffraction | A, B, E | — | — |
| 4PYG | TRANSGLUTAMINASE2 complexed with GTP | x-ray diffraction | A, B, E | — | — |
| 6A8P | Transglutaminase 2 mutant G224V in complex with GTP | x-ray diffraction | A, B, C | GTP | — |
| 6A8P | Transglutaminase 2 mutant G224V in complex with GTP | x-ray diffraction | A, B, C | GTP | — |
| 6KZB | Transglutaminase2 complexed with calcium | x-ray diffraction | A, B, C | CA, GDP | 19 (best 0.85) |
| 6KZB | TRANSGLUTAMINASE2 complexed with calcium | x-ray diffraction | A, B, C | CA, GDP | — |
| 8TR9 | Cryo-EM structure of transglutaminase 2 bound to GDP | electron microscopy | A | GDP | 8 (best 0.65) |
| 9BC2 | Transglutaminase 2 - Open State | x-ray diffraction | A | SO4, CL | 5 (best 0.66) |
| 9BC3 | Transglutaminase 2 - Alternate state | x-ray diffraction | A, B | CA | 6 (best 0.73) |
| 9BC4 | Transglutaminase 2 - Intermediate State | x-ray diffraction | A | CA | 2 (best 0.46) |
| P21980 | AlphaFold monomer V2.0 prediction for protein-glutamine gamma- glutamyltransferase 2 (P21980) | predicted | A | — | 11 (best 0.57) |
Ligands
Experiment against prediction
- 9BC3 chain B against the predicted model P21980: TM-score 0.98, RMSD 1.02 Å
- 9BC4 chain A against the predicted model P21980: TM-score 0.98, RMSD 1.05 Å
- 9BC3 chain A against the predicted model P21980: TM-score 0.98, RMSD 1.12 Å
- 6KZB chain C against the predicted model P21980: TM-score 0.98, RMSD 1.28 Å
- 6KZB chain C against the predicted model P21980: TM-score 0.98, RMSD 1.28 Å
- 8TR9 chain A against the predicted model P21980: TM-score 0.98, RMSD 1.39 Å
- 6A8P chain C against the predicted model P21980: TM-score 0.98, RMSD 1.38 Å
- 6A8P chain C against the predicted model P21980: TM-score 0.98, RMSD 1.38 Å
- 1KV3 chain A against the predicted model P21980: TM-score 0.98, RMSD 1.39 Å
- 1KV3 chain A against the predicted model P21980: TM-score 0.98, RMSD 1.39 Å
Elsewhere
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