Structure of psting complex

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 23% strand (DSSP).

Ligands and binding sites

• 1YD · 2-amino-9-[(2r,3r,3ar,5s,7as,9r,10r,10ar,12r,14as)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-D:3',2'-J][1,3,7,9, 2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one · ligand · chains A, B
• SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1364 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 6A05 · Structure of pSTING complex · the same entry in another collection · chain A against A, TM-score 1.00
• B8XX90 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (B8XX90) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt B8XX90
• Elsewhere: RCSB PDB 6A05 · PDBe 6A05 · UniProt B8XX90