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Crystal structure of human G protein coupled receptor
Analyse Crystal structure of human G protein coupled receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZTY
- Type
- protein
- Length
- 449 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G protein coupled RECEPTOR,T4 LYSOZYME,G protein coupled receptor
- EC
- 3.2.1.17
- UniProt
- P34972, D9IEF7
- Ligands
- 9JU, OLA, SO4
- Pockets
- 4 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G protein coupled RECEPTOR,T4 LYSOZYME,G protein coupled receptor (EC 3.2.1.17) | protein | 449 | 75% helix, 4% strand | P34972, D9IEF7 |
Ligands and binding sites
- 9JU · N-(adamantan-1-yl)-1-(5-hydroxypentyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide · ligand · chains A
- OLA · Oleic acid · ligand · chains A
- SO4 · Sulfate ion · ion · 5 copies · chains A
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 3 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 431 | 0.87 | 0.94 | 50 | 9JU |
| 2 | 159 | 0.40 | 0.73 | 21 | PEG |
| 3 | 66 | 0.35 | 0.76 | 15 | empty |
| 4 | 79 | 0.34 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34972
- Every structure of UniProt D9IEF7
- Elsewhere: RCSB PDB 5ZTY · PDBe 5ZTY · UniProt P34972 · UniProt D9IEF7
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