UniProt P34972
Cannabinoid receptor 2 (P34972)
Cannabinoid receptor 2 (UniProt P34972): 13 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P34972
- Protein
- Cannabinoid receptor 2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 19 · 3 records with a druggable one
Structures
14 records of P34972 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KI9 | Human cannabinoid receptor-2 helix 6 | solution nmr | A | — | — |
| 2KI9 | Human cannabinoid receptor-2 helix 6 | solution nmr | A | — | — |
| 5ZTY | Crystal structure of human G protein coupled receptor | x-ray diffraction | A | 9JU, OLA, SO4 | — |
| 5ZTY | Crystal structure of human G protein coupled receptor | x-ray diffraction | A | 9JU, OLA, SO4 | — |
| 6KPC | Crystal structure of an agonist bound GPCR | x-ray diffraction | A | E3R | — |
| 6KPC | Crystal structure of an agonist bound GPCR | x-ray diffraction | A | E3R | — |
| 6KPF | Cryo-EM structure of a class A GPCR with G protein complex | electron microscopy | R | E3R | — |
| 6KPF | Cryo-EM structure of a class a GPCR with G protein complex | electron microscopy | R | E3R | — |
| 6PT0 | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | electron microscopy | R | WI5, PLM, CLR | — |
| 6PT0 | Cryo-EM structure of human cannabinoid receptor 2-gi protein in complex with agonist win 55,212-2 | electron microscopy | R | WI5, PLM, CLR | — |
| 8GUR | Cryo-EM structure of CP-CB2-G protein complex | electron microscopy | R | 9GF | 6 (best 0.86) |
| 8GUS | Cryo-EM structure of HU-CB2-G protein complex | electron microscopy | R | KO3 | 4 (best 0.86) |
| 8X3L | Cryo-EM structure of CB2-G protein complex | electron microscopy | R | XWD | 9 (best 0.83) |
| P34972 | AlphaFold monomer V2.0 prediction for cannabinoid receptor 2 (P34972) | predicted | A | — | — |
Ligands
- E3R · 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile · in 4 records
- 9JU · N-(adamantan-1-yl)-1-(5-hydroxypentyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide · in 2 records
- CLR · Cholesterol · in 2 records
- OLA · Oleic acid · in 2 records
- PLM · Palmitic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- WI5 · {(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone · in 2 records
- 9GF · 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol · in 1 record
- KO3 · [(1~{S},4~{S},5~{S})-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methanol · in 1 record
- XWD · 4-[3-(4-fluoranyl-2~{H}-indazol-7-yl)-1,2,4-oxadiazol-5-yl]-1-(4-fluorophenyl)azepan-2-one · in 1 record
Experiment against prediction
- 8GUS chain R against the predicted model P34972: TM-score 0.95, RMSD 1.73 Å
- 8GUR chain R against the predicted model P34972: TM-score 0.94, RMSD 1.91 Å
- 6KPF chain R against the predicted model P34972: TM-score 0.94, RMSD 1.87 Å
- 6KPF chain R against the predicted model P34972: TM-score 0.94, RMSD 1.87 Å
- 8X3L chain R against the predicted model P34972: TM-score 0.93, RMSD 2.12 Å
- 6PT0 chain R against the predicted model P34972: TM-score 0.92, RMSD 1.97 Å
- 6PT0 chain R against the predicted model P34972: TM-score 0.92, RMSD 1.97 Å
- 5ZTY chain A against the predicted model P34972: TM-score 0.65, RMSD 1.60 Å
- 5ZTY chain A against the predicted model P34972: TM-score 0.65, RMSD 1.60 Å
- 6KPC chain A against the predicted model P34972: TM-score 0.65, RMSD 1.66 Å
Elsewhere
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