Research workbench
Crystal structure of the dead domain of human EIF4A with sanguinarine
Analyse Crystal structure of the dead domain of human EIF4A with sanguinarine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZBZ
- Type
- protein
- Length
- 218 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic initiation factor 4A-I
- EC
- 3.6.4.13
- UniProt
- P60842
- Ligands
- SAU
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic initiation factor 4A-I (EC 3.6.4.13) | protein | 218 | 45% helix, 14% strand | P60842 |
Ligands and binding sites
- SAU · 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium · ligand · chains A
- MLI · Malonate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.40 | 0.76 | 20 | empty |
Modifications
Observed in the structure: 14 modified (methylation).
Compared structures
- 5ZBZ · Crystal structure of the DEAD domain of Human eIF4A with sanguinarine · the same entry in another collection · chain A against A, TM-score 1.00
- P60842 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60842) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60842
- Elsewhere: RCSB PDB 5ZBZ · PDBe 5ZBZ · UniProt P60842
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.