Research workbench
Structure of the human LAMTOR4-LAMTOR5 complex
Analyse Structure of the human LAMTOR4-LAMTOR5 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5YK5
- Type
- protein
- Length
- 343 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ragulator complex protein LAMTOR4; Ragulator complex protein LAMTOR5
- UniProt
- Q0VGL1, O43504
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 4 distinct chains · 23% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ragulator complex protein LAMTOR4 | protein | 84 | 19% helix, 42% strand | Q0VGL1 |
| B | Ragulator complex protein LAMTOR5 | protein | 89 | 26% helix, 33% strand | O43504 |
| C | Ragulator complex protein LAMTOR4 | protein | 84 | 19% helix, 43% strand | Q0VGL1 |
| D | Ragulator complex protein LAMTOR5 | protein | 86 | 28% helix, 31% strand | O43504 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.49 | 0.80 | 25 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1102 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1078 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 667 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 310 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 222 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5YK5 · structure of the human Lamtor4-Lamtor5 complex · the same entry in another collection · chain D against D, TM-score 1.00
- O43504 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR5 (O43504) · a predicted model of the same protein · chain D against A, TM-score 0.98
- Q0VGL1 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR4 (Q0VGL1) · a predicted model of the same protein · chain C against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0VGL1
- Every structure of UniProt O43504
- Elsewhere: RCSB PDB 5YK5 · PDBe 5YK5 · UniProt Q0VGL1 · UniProt O43504
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