UniProt O43504
Ragulator complex protein LAMTOR5 (O43504)
Ragulator complex protein LAMTOR5 (UniProt O43504): 36 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43504
- Protein
- Ragulator complex protein LAMTOR5
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 52 · 12 records with a druggable one
Structures
37 records of O43504 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3MS6 | Crystal structure of Hepatitis B X-Interacting Protein (HBXIP) | x-ray diffraction | A | — | — |
| 3MS6 | Crystal structure of hepatitis B X-interacting protein (hbxip) | x-ray diffraction | A | — | — |
| 3MSH | Crystal structure of Hepatitis B X-Interacting Protein at high resolution | x-ray diffraction | A | — | — |
| 3MSH | Crystal structure of hepatitis B X-interacting protein at high resolution | x-ray diffraction | A | — | — |
| 5VOK | Crystal structure of the C7orf59-HBXIP dimer | x-ray diffraction | A, C, E, G | — | 10 (best 0.61) |
| 5VOK | Crystal structure of the C7ORF59-hbxip dimer | x-ray diffraction | A, C, E, G | — | — |
| 5X6U | Crystal structure of human heteropentameric complex | x-ray diffraction | C | — | 5 (best 0.61) |
| 5X6U | Crystal structure of human heteropentameric complex | x-ray diffraction | C | — | — |
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | C | NA | 4 (best 0.70) |
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | C | NA | — |
| 5Y38 | Crystal structure of C7orf59-HBXIP complex | x-ray diffraction | A | SO4 | — |
| 5Y38 | Crystal structure of C7ORF59-hbxip complex | x-ray diffraction | A | SO4 | — |
| 5Y39 | Crystal structure of Ragulator complex (p18 76-145) | x-ray diffraction | E, J | — | — |
| 5Y39 | Crystal structure of ragulator complex (P18 76-145) | x-ray diffraction | E, J | — | — |
| 5Y3A | Crystal structure of Ragulator complex (p18 49-161) | x-ray diffraction | E, J | SO4 | 12 (best 0.71) |
| 5Y3A | Crystal structure of ragulator complex (P18 49-161) | x-ray diffraction | E, J | SO4 | — |
| 5YK3 | human Ragulator complex | x-ray diffraction | o, E, J | — | — |
| 5YK3 | Human ragulator complex | x-ray diffraction | o, E, J | — | — |
| 5YK5 | structure of the human Lamtor4-Lamtor5 complex | x-ray diffraction | B, D | — | 1 (best 0.49) |
| 5YK5 | Structure of the human LAMTOR4-LAMTOR5 complex | x-ray diffraction | B, D | — | — |
| 6EHP | The crystal structure of the human LAMTOR complex | x-ray diffraction | C | — | 4 (best 0.68) |
| 6EHP | The crystal structure of the human lamtor complex | x-ray diffraction | C | — | — |
| 6EHR | The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex | x-ray diffraction | C | — | 4 (best 0.72) |
| 6EHR | The crystal structure of the human lamtor-raga ctd-ragc ctd complex | x-ray diffraction | C | — | — |
| 6U62 | Raptor-Rag-Ragulator complex | electron microscopy | H | — | 2 (best 0.77) |
| 6U62 | Raptor-rag-ragulator complex | electron microscopy | H | — | — |
| 6ULG | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | electron microscopy | C | — | 2 (best 0.68) |
| 6ULG | Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex | electron microscopy | C | — | — |
| 7T3A | GATOR1-RAG-RAGULATOR - Inhibitory Complex | electron microscopy | Q | — | 1 (best 0.67) |
| 7T3A | GATOR1-rag-ragulator - inhibitory complex | electron microscopy | Q | — | — |
| 7T3B | GATOR1-RAG-RAGULATOR - GAP Complex | electron microscopy | J | — | 4 (best 0.73) |
| 7T3B | GATOR1-rag-ragulator - gap complex | electron microscopy | J | — | — |
| 7T3C | GATOR1-RAG-RAGULATOR - Dual Complex | electron microscopy | J, Q | — | 1 (best 0.75) |
| 7T3C | GATOR1-rag-ragulator - dual complex | electron microscopy | J, Q | — | — |
| 7UXC | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion | electron microscopy | J, Q | — | 2 (best 0.64) |
| 7UXH | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | electron microscopy | L, S, b, i | — | — |
| O43504 | AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR5 (O43504) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5YK5 chain D against the predicted model O43504: TM-score 0.98, RMSD 0.69 Å
- 5YK5 chain D against the predicted model O43504: TM-score 0.98, RMSD 0.69 Å
- 5Y39 chain E against the predicted model O43504: TM-score 0.97, RMSD 0.72 Å
- 5Y39 chain E against the predicted model O43504: TM-score 0.97, RMSD 0.72 Å
- 6EHP chain C against the predicted model O43504: TM-score 0.96, RMSD 0.77 Å
- 6EHP chain C against the predicted model O43504: TM-score 0.96, RMSD 0.77 Å
- 5X6U chain C against the predicted model O43504: TM-score 0.96, RMSD 0.79 Å
- 5X6U chain C against the predicted model O43504: TM-score 0.96, RMSD 0.79 Å
- 5YK3 chain E against the predicted model O43504: TM-score 0.96, RMSD 0.87 Å
- 5YK3 chain E against the predicted model O43504: TM-score 0.96, RMSD 0.87 Å
Elsewhere
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