Research workbench
Pig gastric H+,K+ - ATPase in complex with BYK99
Analyse Pig gastric H+,K+ - ATPase in complex with BYK99 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Y0B
- Type
- protein
- Length
- 1,161 residues
- Chains
- 2
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium-transporting ATPase alpha chain 1; Potassium-transporting ATPase subunit beta
- EC
- 3.6.3.10
- UniProt
- P19156, P18434
- Pockets
- 18 · best druggability 0.79
Structure
electron crystallography · 2 distinct chains · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) | protein | 986 | 50% helix, 15% strand | P19156 |
| B | Potassium-transporting ATPase subunit beta | protein | 175 | 18% helix, 10% strand | P18434 |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 778 | 0.79 | 0.82 | 87 | empty |
| 2 | 58 | 0.73 | 0.99 | 20 | empty |
| 3 | 516 | 0.73 | 0.81 | 59 | empty |
| 4 | 219 | 0.60 | 0.81 | 28 | empty |
| 5 | 79 | 0.59 | 0.87 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 2132 Ų buried · 30 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5Y0B · PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 · the same entry in another collection · chain A against A, TM-score 1.00
- P19156 · AlphaFold monomer V2.0 prediction for potassium-transporting ATPase alpha chain 1 (P19156) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P18434 · AlphaFold monomer V2.0 prediction for potassium-transporting ATPase subunit beta (P18434) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19156
- Every structure of UniProt P18434
- Elsewhere: RCSB PDB 5Y0B · PDBe 5Y0B · UniProt P19156 · UniProt P18434
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.