UniProt P19156
Potassium-transporting ATPase alpha chain 1 (P19156)
Potassium-transporting ATPase alpha chain 1 (UniProt P19156), EC 3.6.3.10: 33 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P19156
- Protein
- Potassium-transporting ATPase alpha chain 1
- EC
- 3.6.3.10
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 52 · 3 records with a druggable one
Structures
34 records of P19156 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IWC | TFE-induded structure of the N-terminal domain of pig gastric H/K-ATPase | solution nmr | A | — | — |
| 1IWC | Tfe-induded structure of the N-terminal domain of pig gastric H/K- ATPase | solution nmr | A | — | — |
| 1IWF | Solution structure of the N-terminal domain of pig gastric H/K-ATPase | solution nmr | A | — | — |
| 1IWF | Solution structure of the N-terminal domain of pig gastric H/K-ATPase | solution nmr | A | — | — |
| 2XZB | Pig Gastric H,K-ATPase with bound BeF and SCH28080 | electron crystallography | A | — | — |
| 2XZB | Pig gastric H,K-ATPase with bound bef and SCH28080 | electron crystallography | A | — | — |
| 2YN9 | Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium | electron crystallography | A | — | — |
| 2YN9 | Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium | electron crystallography | A | — | — |
| 3IXZ | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | electron crystallography | A | — | — |
| 3IXZ | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | electron crystallography | A | — | — |
| 4UX1 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. AlF) | electron crystallography | A | — | — |
| 4UX1 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2.ALF) | electron crystallography | A | — | — |
| 4UX2 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. MgF) | electron crystallography | A | — | — |
| 4UX2 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2.MGF) | electron crystallography | A | — | — |
| 5Y0B | PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 | electron crystallography | A | — | 18 (best 0.79) |
| 5Y0B | Pig gastric H+,K+ - ATPase in complex with BYK99 | electron crystallography | A | — | — |
| 5YLU | Crystal structure of the gastric proton pump complexed with vonoprazan | x-ray diffraction | A | HKT, PCW, MG, CE1 | — |
| 5YLV | Crystal structure of the gastric proton pump complexed with SCH28080 | x-ray diffraction | A | 8WX, MG, CE1, RB, PCW | — |
| 5YLV | Crystal structure of the gastric proton pump complexed with SCH28080 | x-ray diffraction | A | 8WX, MG, CE1, RB, PCW | — |
| 6JXH | K+-bound E2-MgF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | A | MF4, MG, PCW, CE1, K, CLR | — |
| 6JXH | K+-bound E2-mgf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | A | MF4, MG, PCW, CE1, K, CLR | — |
| 6JXI | Rb+-bound E2-MgF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | A | MF4, PCW, CE1, MG, RB, CLR | — |
| 6JXI | Rb+-bound E2-mgf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | A | MF4, PCW, CE1, MG, RB, CLR | — |
| 6JXJ | Rb+-bound E2-AlF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | A | MG, PCW, CE1, ALF, RB, CLR | — |
| 6JXJ | Rb+-bound E2-alf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | A | MG, PCW, CE1, ALF, RB, CLR | — |
| 6JXK | Rb+-bound E2-MgF state of the gastric proton pump (Wild-type) | x-ray diffraction | A, E | MF4, MG, CLR, K | — |
| 6JXK | Rb+-bound E2-mgf state of the gastric proton pump (wild-type) | x-ray diffraction | A, E | MF4, MG, CLR, K | — |
| 7W47 | Crystal structure of the gastric proton pump complexed with tegoprazan | x-ray diffraction | A | MG, RB, 8BN | — |
| 7W48 | Crystal structure of the gastric proton pump complexed with pf- 03716556 | x-ray diffraction | A | MG, CE1, RB, 8BZ, PCW | — |
| 7W49 | Crystal structure of the gastric proton pump complexed with soraprazan | x-ray diffraction | A | MG, RB, 8CE | 18 (best 0.76) |
| 7W49 | Crystal structure of the gastric proton pump complexed with soraprazan | x-ray diffraction | A | MG, RB, 8CE | — |
| 7W4A | Cryo-EM structure of the gastric proton pump complexed with revaprazan | electron microscopy | A | 8CK, NA, MG, PCW | 16 (best 0.77) |
| 7W4A | Cryo-EM structure of the gastric proton pump complexed with revaprazan | electron microscopy | A | 8CK, NA, MG, PCW | — |
| P19156 | AlphaFold monomer V2.0 prediction for potassium-transporting ATPase alpha chain 1 (P19156) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 17 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 12 records
- CE1 · O-dodecanyl octaethylene glycol · in 10 records
- RB · Rubidium ion · in 10 records
- CLR · Cholesterol · in 8 records
- MF4 · Tetrafluoromagnesate(2-) · in 6 records
- K · Potassium ion · in 4 records
- 8CE · Soraprazan · in 2 records
- 8CK · N-(4-fluorophenyl)-4,5-dimethyl-6-[(1R)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]pyrimidin-2-amine · in 2 records
- 8WX · 2-(2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyridin-3-yl)ethanenitrile · in 2 records
- ALF · Tetrafluoroaluminate ion · in 2 records
- NA · Sodium ion · in 2 records
- 8BN · Tegoprazan · in 1 record
- 8BZ · N-(2-hydroxyethyl)-N,2-dimethyl-8-[[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino]imidazo[1,2-a]pyridine-6-carboxamide · in 1 record
- HKT · 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine · in 1 record
Experiment against prediction
- 6JXK chain A against the predicted model P19156: TM-score 0.99, RMSD 1.17 Å
- 6JXK chain A against the predicted model P19156: TM-score 0.99, RMSD 1.17 Å
- 6JXK chain E against the predicted model P19156: TM-score 0.99, RMSD 1.22 Å
- 6JXK chain E against the predicted model P19156: TM-score 0.99, RMSD 1.22 Å
- 6JXH chain A against the predicted model P19156: TM-score 0.99, RMSD 1.27 Å
- 6JXH chain A against the predicted model P19156: TM-score 0.99, RMSD 1.27 Å
- 6JXI chain A against the predicted model P19156: TM-score 0.99, RMSD 1.30 Å
- 6JXI chain A against the predicted model P19156: TM-score 0.99, RMSD 1.30 Å
- 6JXJ chain A against the predicted model P19156: TM-score 0.99, RMSD 1.30 Å
- 6JXJ chain A against the predicted model P19156: TM-score 0.99, RMSD 1.30 Å
Elsewhere
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