Research workbench
Complex structure of angiotensin II type 2 receptor with Fab
Analyse Complex structure of angiotensin II type 2 receptor with Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XJM
- Type
- protein
- Length
- 815 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type-2 angiotensin II RECEPTOR,SOLUBLE cytochrome B562, type-2 angiotensin II receptor…
- UniProt
- P50052, P0ABE7
- Pockets
- 9 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type-2 angiotensin II RECEPTOR,SOLUBLE cytochrome B562, type-2 angiotensin II receptor | protein | 375 | 79% helix, 3% strand | P50052, P0ABE7 |
| H | Fabh | protein | 220 | 3% helix, 50% strand | — |
| L | Fabl | protein | 212 | 7% helix, 53% strand | — |
| B | SAR1, ILE8-angiotensin II | protein | 8 | 0% helix, 0% strand | — |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.70 | 0.81 | 35 | empty |
| 2 | 649 | 0.66 | 0.75 | 61 | empty |
| 3 | 74 | 0.63 | 0.90 | 20 | empty |
| 4 | 258 | 0.58 | 0.78 | 38 | empty |
| 5 | 226 | 0.53 | 0.77 | 42 | empty |
Interfaces
4 interfaces between chains.
- H–L · 1816 Ų buried · 12 hydrogen bonds · protein-protein
- A–H · 838 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 797 Ų buried · 11 hydrogen bonds · protein-protein
- A–L · 324 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 1 modified (disulfide, methylation).
Compared structures
- 5XJM · Complex structure of angiotensin II type 2 receptor with Fab · the same entry in another collection · chain A against A, TM-score 1.00
- P50052 · AlphaFold monomer V2.0 prediction for type-2 angiotensin II receptor (P50052) · a predicted model of the same protein · chain A against A, TM-score 0.75
- P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50052
- Every structure of UniProt P0ABE7
- Elsewhere: RCSB PDB 5XJM · PDBe 5XJM · UniProt P50052 · UniProt P0ABE7
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