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Crystal structure of murine receptor-interacting protein 4 (RIPK4) D143N bound to staurosporine
Analyse Crystal structure of murine receptor-interacting protein 4 (RIPK4) D143N bound… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WNL
- Type
- protein
- Length
- 262 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-interacting SERINE/THREONINE-protein kinase 4
- EC
- 2.7.11.1
- UniProt
- Q9ERK0
- Ligands
- STU, CL
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-interacting SERINE/THREONINE-protein kinase 4 (EC 2.7.11.1) | protein | 262 | 41% helix, 18% strand | Q9ERK0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.64 | 0.80 | 35 | STU |
| 2 | 175 | 0.57 | 0.81 | 29 | empty |
| 3 | 79 | 0.37 | 0.77 | 22 | empty |
Compared structures
- 5WNL · Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9ERK0 · AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ERK0
- Elsewhere: RCSB PDB 5WNL · PDBe 5WNL · UniProt Q9ERK0
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