UniProt Q9ERK0
Receptor-interacting SERINE/THREONINE-protein kinase 4 (Q9ERK0)
Receptor-interacting SERINE/THREONINE-protein kinase 4 (UniProt Q9ERK0): 6 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9ERK0
- Protein
- Receptor-interacting SERINE/THREONINE-protein kinase 4
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 7 · 1 record with a druggable one
Structures
7 records of Q9ERK0 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WNI | Crystal structure of murine receptor-interacting protein kinase 4 (RIPK4) D143N in complex with ATP | x-ray diffraction | A | MG, CL, ATP | — |
| 5WNJ | Crystal structure of murine receptor-interacting protein kinase 4 (RIPK4) D143N in complex with… | x-ray diffraction | A | 2V9, CL | — |
| 5WNK | Crystal structure of murine receptor-interacting protein 4 (RIPK4) D143N bound to TG100-115 | x-ray diffraction | A | CL, B6J | — |
| 5WNL | Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to staurosporine | x-ray diffraction | A | STU, CL | — |
| 5WNL | Crystal structure of murine receptor-interacting protein 4 (RIPK4) D143N bound to staurosporine | x-ray diffraction | A | STU, CL | — |
| 5WNM | Crystal structure of murine receptor-interacting protein 4 (RIPK4) D143N bound to tozasertib… | x-ray diffraction | A | CL, VX6 | — |
| Q9ERK0 | AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 4… | predicted | A | — | 7 (best 0.75) |
Ligands
- CL · Chloride ion · in 6 records
- STU · Staurosporine · in 2 records
- 2V9 · Lestaurtinib · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- B6J · 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol · in 1 record
- MG · Magnesium ion · in 1 record
- VX6 · Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide · in 1 record
Experiment against prediction
- 5WNJ chain A against the predicted model Q9ERK0: TM-score 0.96, RMSD 1.53 Å
- 5WNK chain A against the predicted model Q9ERK0: TM-score 0.96, RMSD 1.56 Å
- 5WNM chain A against the predicted model Q9ERK0: TM-score 0.96, RMSD 1.55 Å
- 5WNL chain A against the predicted model Q9ERK0: TM-score 0.96, RMSD 1.57 Å
- 5WNL chain A against the predicted model Q9ERK0: TM-score 0.96, RMSD 1.57 Å
- 5WNI chain A against the predicted model Q9ERK0: TM-score 0.95, RMSD 1.71 Å
Elsewhere
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