Crystal structure of human CD22 ig domains 1-3 in complex with alpha 2-6 sialyllactose

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 57% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
• BMA · beta-D-mannopyranose · sugar · chains A
• GAL · beta-D-galactopyranose · sugar · chains A
• SIA · N-acetyl-alpha-neuraminic acid · sugar · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 5VKM · Crystal structure of human CD22 Ig domains 1-3 in complex with alpha 2-6 sialyllactose · the same entry in another collection · chain A against A, TM-score 1.00
• P20273 · AlphaFold monomer V2.0 prediction for B-cell receptor CD22 (P20273) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P20273
• Elsewhere: RCSB PDB 5VKM · PDBe 5VKM · UniProt P20273