Research workbench
1.8A resolution structure of latent plasminogen activator inhibitor-1(PAI-1)
Analyse 1.8A resolution structure of latent plasminogen activator inhibitor-1(PAI-1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LJ5
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator inhibitor-1
- UniProt
- P05121
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasminogen activator inhibitor-1 | protein | 379 | 29% helix, 35% strand | P05121 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.64 | 0.88 | 25 | empty |
| 2 | 204 | 0.55 | 0.79 | 23 | empty |
| 3 | 113 | 0.47 | 0.78 | 22 | empty |
| 4 | 65 | 0.43 | 0.81 | 19 | empty |
Compared structures
- 1LJ5 · 1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1) · the same entry in another collection · chain A against A, TM-score 1.00
- P05121 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05121
- Elsewhere: RCSB PDB 1LJ5 · PDBe 1LJ5 · UniProt P05121
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