UniProt P05121
Plasminogen activator inhibitor 1 (P05121)
Plasminogen activator inhibitor 1 (UniProt P05121): 55 experimental structures on GenesisL1, 1 ligand bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P05121
- Protein
- Plasminogen activator inhibitor 1
- Experimental structures
- 55
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
55 records of P05121 in the MolNFT archive: 55 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A7C | Human plasminogen activator inhibitor type-1 in complex with a pentapeptide | x-ray diffraction | A | — | — |
| 1A7C | Human plasminogen activator inhibitor type-1 in complex with a pentapeptide | x-ray diffraction | A | — | — |
| 1B3K | Plasminogen activator inhibitor-1 | x-ray diffraction | A, B, C, D | — | — |
| 1B3K | Plasminogen activator inhibitor-1 | x-ray diffraction | A, B, C, D | — | — |
| 1C5G | Plasminogen activator inhibitor-1 | x-ray diffraction | A | — | — |
| 1C5G | Plasminogen activator inhibitor-1 | x-ray diffraction | A | — | — |
| 1DB2 | Crystal structure of native plasminogen activator inhibitor-1 | x-ray diffraction | A, B | — | — |
| 1DB2 | Crystal structure of native plasminogen activator inhibitor-1 | x-ray diffraction | A, B | — | — |
| 1DVM | Active form of human pai-1 | x-ray diffraction | A, B, C, D | — | — |
| 1DVM | Active form of human pai-1 | x-ray diffraction | A, B, C, D | — | — |
| 1DVN | Latent form of plasminogen activator inhibitor-1 (pai-1) | x-ray diffraction | A | — | — |
| 1DVN | Latent form of plasminogen activator inhibitor-1 (pai-1) | x-ray diffraction | A | — | — |
| 1LJ5 | 1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1) | x-ray diffraction | A | — | — |
| 1LJ5 | 1.8A resolution structure of latent plasminogen activator inhibitor-1(PAI-1) | x-ray diffraction | A | — | — |
| 1OC0 | plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin | x-ray diffraction | A | — | — |
| 1OC0 | Plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin | x-ray diffraction | A | — | — |
| 3CVM | High resolution structure of a stable Plasminogen activator inhibitor type-1 in its protease… | x-ray diffraction | A, B | — | — |
| 3CVM | High resolution structure of a stable plasminogen activator inhibitor type-1 in its protease… | x-ray diffraction | A, B | — | — |
| 3EOX | High quality structure of cleaved PAI-1-stab | x-ray diffraction | A | — | — |
| 3EOX | High quality structure of cleaved pai-1-stab | x-ray diffraction | A | — | — |
| 3PB1 | Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and… | x-ray diffraction | I | — | — |
| 3PB1 | Crystal structure of a michaelis complex between plasminogen activator inhibitor-1 and… | x-ray diffraction | I | — | — |
| 3Q02 | Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation. | x-ray diffraction | A, B | — | — |
| 3Q02 | Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation. | x-ray diffraction | A, B | — | — |
| 3Q03 | Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation. | x-ray diffraction | A, B | — | — |
| 3Q03 | Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation. | x-ray diffraction | A, B | — | — |
| 3R4L | Human very long half life Plasminogen Activator Inhibitor type-1 | x-ray diffraction | A | — | — |
| 3R4L | Human very long half life plasminogen activator inhibitor type-1 | x-ray diffraction | A | — | — |
| 3UT3 | A novel PAI-I inhibitor and its structural mechanism | x-ray diffraction | A, B, C, D | — | — |
| 3UT3 | A novel pai-I inhibitor and its structural mechanism | x-ray diffraction | A, B, C, D | — | — |
| 4AQH | Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976 | x-ray diffraction | A, B, C | — | — |
| 4AQH | Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976 | x-ray diffraction | A, B, C | — | — |
| 4G8O | Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | x-ray diffraction | A, B, C, D | — | — |
| 4G8O | Crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | x-ray diffraction | A, B, C, D | — | — |
| 4G8R | Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | x-ray diffraction | A, B | — | — |
| 4G8R | Crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | x-ray diffraction | A, B | — | — |
| 4IC0 | Crystal Structure of PAI-1 in Complex with Gallate | x-ray diffraction | A, B, C, D | — | — |
| 4IC0 | Crystal structure of pai-1 in complex with gallate | x-ray diffraction | A, B, C, D | — | — |
| 5BRR | Michaelis complex of tPA-S195A:PAI-1 | x-ray diffraction | I | — | 5 (best 0.65) |
| 5BRR | Michaelis complex of tpa-S195A:PAI-1 | x-ray diffraction | I | — | — |
| 5ZLZ | Structure of tPA and PAI-1 | x-ray diffraction | I | — | — |
| 5ZLZ | Structure of tpa and pai-1 | x-ray diffraction | I | — | — |
| 6GWN | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex… | x-ray diffraction | A | — | — |
| 6GWN | Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-W175F) in complex… | x-ray diffraction | A | — | — |
| 6GWP | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex… | x-ray diffraction | A | — | — |
| 6GWP | Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-stab) in complex… | x-ray diffraction | A | — | — |
| 6GWQ | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex… | x-ray diffraction | A | — | — |
| 6GWQ | Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-stab) in complex… | x-ray diffraction | A | — | — |
| 6I8S | Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of… | x-ray diffraction | A, B, C, D | — | — |
| 6I8S | Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of… | x-ray diffraction | A, B, C, D | — | — |
| 6ZRV | Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-W175F) in complex… | x-ray diffraction | A | — | — |
| 7AQF | Crystal structure of small molecule inhibitor TM5484 bound to stabilized active plasminogen… | x-ray diffraction | A, B | RV2 | — |
| 7AQG | Crystal structure of small molecule inhibitor TM5484 bound to stabilized active plasminogen… | x-ray diffraction | A | RV2 | — |
| 9PAI | Cleaved substrate variant of plasminogen activator inhibitor-1 | x-ray diffraction | A, B | — | — |
| P05121 | AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) | — | — | — |
Ligands
- RV2 · 5-chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid · in 2 records
Elsewhere
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