Research workbench
CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42 - unrefined
Analyse CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UPL
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase pak 4; Cell division control protein 42 homolog
- EC
- 2.7.11.1
- UniProt
- O96013, P60953
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase pak 4 (EC 2.7.11.1) | protein | 291 | 40% helix, 18% strand | O96013 |
| B | Cell division control protein 42 homolog | protein | 176 | 37% helix, 23% strand | P60953 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.64 | 0.75 | 54 | empty |
| 2 | 234 | 0.62 | 0.81 | 33 | empty |
| 3 | 124 | 0.53 | 0.81 | 15 | empty |
| 4 | 75 | 0.39 | 0.78 | 16 | empty |
| 5 | 50 | 0.28 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 246 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5UPL · CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42… · the same entry in another collection · chain A against A, TM-score 1.00
- P60953 · AlphaFold monomer V2.0 prediction for cell division control protein 42 homolog (P60953) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O96013 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pak 4 (O96013) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O96013
- Every structure of UniProt P60953
- Elsewhere: RCSB PDB 5UPL · PDBe 5UPL · UniProt O96013 · UniProt P60953
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