UniProt O96013
Serine/threonine-protein kinase PAK 4 (O96013)
Serine/threonine-protein kinase PAK 4 (UniProt O96013), EC 2.7.11.1: 78 experimental structures on GenesisL1, 16 ligands bound, 26 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O96013
- Protein
- Serine/threonine-protein kinase PAK 4
- EC
- 2.7.11.1
- Experimental structures
- 78
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 26 · 12 records with a druggable one
Structures
78 records of O96013 in the MolNFT archive: 78 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CDZ | Crystal structure of the human P21-activated kinase 4 in complex with CGP74514A | x-ray diffraction | A | — | — |
| 2CDZ | Crystal structure of the human P21-activated kinase 4 in complex with CGP74514A | x-ray diffraction | A | — | — |
| 2J0I | Crystal structure of the human P21-activated kinase 4 | x-ray diffraction | A | — | — |
| 2J0I | Crystal structure of the human P21-activated kinase 4 | x-ray diffraction | A | — | — |
| 2OV2 | The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated… | x-ray diffraction | I, J, K, L, M, N, O, P | — | — |
| 2OV2 | The crystal structure of the human RAC3 in complex with the crib domain of human P21-activated… | x-ray diffraction | I, J, K, L, M, N, O, P | — | — |
| 2Q0N | Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide | x-ray diffraction | A | — | — |
| 2Q0N | Structure of human P21 activating kinase 4 (PAK4) in complex with a consensus peptide | x-ray diffraction | A | — | — |
| 2X4Z | Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309 | x-ray diffraction | A | — | — |
| 2X4Z | Crystal structure of the human P21-activated kinase 4 in complex with pf-03758309 | x-ray diffraction | A | — | — |
| 4APP | Crystal Structure of the Human p21-Activated Kinase 4 in Complex with… | x-ray diffraction | A | — | — |
| 4APP | Crystal structure of the human P21-activated kinase 4 in complex with… | x-ray diffraction | A | — | — |
| 4FIE | Full-length human PAK4 | x-ray diffraction | A, B | — | — |
| 4FIE | Full-length human PAK4 | x-ray diffraction | A, B | — | — |
| 4FIF | Catalytic domain of human PAK4 with RPKPLVDP peptide | x-ray diffraction | A, B, C, D | — | — |
| 4FIF | Catalytic domain of human PAK4 with rpkplvdp peptide | x-ray diffraction | A, B, C, D | — | — |
| 4FIG | Catalytic domain of human PAK4 | x-ray diffraction | A, B | — | — |
| 4FIG | Catalytic domain of human PAK4 | x-ray diffraction | A, B | — | — |
| 4FIH | Catalytic domain of human PAK4 with QKFTGLPRQW peptide | x-ray diffraction | A | — | — |
| 4FIH | Catalytic domain of human PAK4 with qkftglprqw peptide | x-ray diffraction | A | — | — |
| 4FII | Catalytic domain of human PAK4 with RPKPLVDP peptide | x-ray diffraction | A, B | — | — |
| 4FII | Catalytic domain of human PAK4 with rpkplvdp peptide | x-ray diffraction | A, B | — | — |
| 4FIJ | Catalytic domain of human PAK4 | x-ray diffraction | A | — | — |
| 4FIJ | Catalytic domain of human PAK4 | x-ray diffraction | A | — | — |
| 4JDH | Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T peptide… | x-ray diffraction | A | — | — |
| 4JDH | Crystal structure of SERINE/THREONINE-protein kinase pak 4 in complex with paktide T peptide… | x-ray diffraction | A | — | — |
| 4JDI | Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S peptide… | x-ray diffraction | A | — | — |
| 4JDI | Crystal structure of SERINE/THREONINE-protein kinase pak 4 in complex with paktide S peptide… | x-ray diffraction | A | — | — |
| 4JDJ | Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide T… | x-ray diffraction | A | — | — |
| 4JDJ | Crystal structure of SERINE/THREONINE-protein kinase pak 4 F461V mutant in complex with paktide T… | x-ray diffraction | A | — | — |
| 4JDK | Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide S… | x-ray diffraction | A | — | — |
| 4JDK | Crystal structure of SERINE/THREONINE-protein kinase pak 4 F461V mutant in complex with paktide S… | x-ray diffraction | A | — | — |
| 4L67 | Crystal Structure of Catalytic Domain of PAK4 | x-ray diffraction | A, B | — | — |
| 4L67 | Crystal structure of catalytic domain of PAK4 | x-ray diffraction | A, B | — | — |
| 4NJD | Structure of p21-activated kinase 4 with a novel inhibitor KY-04031 | x-ray diffraction | A | — | — |
| 4NJD | Structure of P21-activated kinase 4 with a novel inhibitor ky-04031 | x-ray diffraction | A | — | — |
| 4O0V | Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4O0V | Back pocket flexibility provides group-II pak selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4O0X | Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4O0X | Back pocket flexibility provides group-II pak selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4O0Y | Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4O0Y | Back pocket flexibility provides group-II pak selectivity for type 1 kinase inhibitors | x-ray diffraction | A | — | — |
| 4XBR | In cellulo Crystal Structure of PAK4 in complex with Inka | x-ray diffraction | A | ATP, MG | 3 (best 0.64) |
| 4XBR | In cellulo crystal structure of PAK4 in complex with inka | x-ray diffraction | A | — | — |
| 4XBU | In vitro Crystal Structure of PAK4 in complex with Inka peptide | x-ray diffraction | A | — | — |
| 4XBU | In vitro crystal structure of PAK4 in complex with inka peptide | x-ray diffraction | A | — | — |
| 5BMS | Crystal structure of P21-activated kinase 4 in complex with an inhibitor compound 29 | x-ray diffraction | A | — | — |
| 5BMS | Crystal structure of P21-activated kinase 4 in complex with an inhibitor compound 29 | x-ray diffraction | A | — | — |
| 5I0B | Structure of PAK4 | x-ray diffraction | A | 67U | — |
| 5I0B | Structure of PAK4 | x-ray diffraction | A | — | — |
| 5UPK | CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4CAT, PAK4-N45, CDC42 | x-ray diffraction | A, B | ANP | — |
| 5UPL | CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42 - UNREFINED | x-ray diffraction | A | — | — |
| 5UPL | CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42 - unrefined | x-ray diffraction | A | — | — |
| 5VED | PAK4 kinase domain in complex with Staurosporine | x-ray diffraction | A | STU | — |
| 5VED | PAK4 kinase domain in complex with staurosporine | x-ray diffraction | A | STU | — |
| 5VEE | PAK4 kinase domain in complex with FRAX486 | x-ray diffraction | A | 981 | 2 (best 0.71) |
| 5VEE | PAK4 kinase domain in complex with FRAX486 | x-ray diffraction | A | 981 | — |
| 5VEF | PAK4 kinase domain in complex with fasudil | x-ray diffraction | A | M77 | 2 (best 0.66) |
| 5VEF | PAK4 kinase domain in complex with fasudil | x-ray diffraction | A | M77 | — |
| 5XVA | Crystal structure of PAK4 in complex with inhibitor CZH216 | x-ray diffraction | A | 8FU | — |
18 records more on the page itself.
Ligands
- 8FR · 2-(4-azanylpiperidin-1-yl)-6-chloranyl-N-(1-methylimidazol-4-yl)quinazolin-4-amine · in 2 records
- 8FX · [6-chloranyl-4-[(5-cyclopropyl-1H-pyrazol-3-yl) amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone · in 2 records
- 981 · 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one · in 2 records
- 9EO · (3Z)-N-[(1S)-2-hydroxy-1-phenylethyl]-3-[(1H-imidazol-2-yl)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide · in 2 records
- BCT · Bicarbonate ion · in 2 records
- G5X · 1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl) ethynyl]indole-3-carboxamide · in 2 records
- M77 · 5-(1,4-diazepan-1-sulfonyl)isoquinoline · in 2 records
- STU · Staurosporine · in 2 records
- 67U · 6-bromo-2-[1-methyl-3-(propan-2-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridine · in 1 record
- 8FU · [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl) amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- GC6 · [(3R)-3-azanylpiperidin-1-yl]-[1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl)ethynyl]indol-3-yl]methanone · in 1 record
- GCC · [1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl)ethynyl]indol-3-yl]-[(3S)-3-methylpiperazin-1-yl]methanone · in 1 record
- M56 · ~{N}-methyl-1,3-benzothiazole-6-carboxamide · in 1 record
- MG · Magnesium ion · in 1 record
Elsewhere
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