Research workbench
Complex of NOTCH1(EGF8-12) bound to JAGGED1(N-EGF3)
Analyse Complex of NOTCH1(EGF8-12) bound to JAGGED1(N-EGF3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UK5
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q07008, Q63722
- Ligands
- BGC, FUC, NAG, XYS, CA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 194 | — | Q07008 |
| B | — | protein | 308 | — | Q63722 |
Ligands and binding sites
- BGC · beta-D-glucopyranose · sugar · 3 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · 3 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
- XYS · alpha-D-xylopyranose · sugar · chains A
- CA · Calcium ion · metal · 3 copies · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UK5 · Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) · the same entry in another collection · chain A against A, TM-score 1.00
- Q63722 · AlphaFold monomer V2.0 prediction for protein jagged-1 (Q63722) · a predicted model of the same protein · chain B against A, TM-score 0.70
- Q07008 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (Q07008) · a predicted model of the same protein · chain A against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07008
- Every structure of UniProt Q63722
- Elsewhere: RCSB PDB 5UK5 · PDBe 5UK5 · UniProt Q07008 · UniProt Q63722
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