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Factor viia in complex with the inhibitor (5R,11R)-11-[(1-amino-4- fluoroisoquinolin-6-YL)AMINO]-16-(cyclopropylsulfonyl)-7-(2,2- difluoroethoxy)-5,13-dimethyl-2,13-DIAZATRICYCLO[13.3.1.1~6, 10~]ICOSA-1(19),6(20),7,9,15,17-hexaene-3,12-dione

Analyse Factor viia in complex with the inhibitor (5R,11R)-11-[(1-amino-4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TQG
Type: protein
Length: 305 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P08709
Ligands: 7KS, CA, SO4

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	—	protein	250	—	P08709
L	—	protein	55	—	P08709

Ligands and binding sites

7KS · (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione · ligand · chains H
CA · Calcium ion · metal · chains H
SO4 · Sulfate ion · ion · 4 copies · chains H, L
GOL · Glycerol · additive · 4 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

P08709 · AlphaFold monomer V2.0 prediction for coagulation factor VII (P08709) · a predicted model of the same protein · chain H against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08709
Elsewhere: RCSB PDB 5TQG · PDBe 5TQG · UniProt P08709

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