Research workbench
Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R
Analyse Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5THL
- Type
- protein
- Length
- 330 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.1
- UniProt
- P54577
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) | protein | 330 | 56% helix, 12% strand | P54577 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.67 | 0.78 | 55 | empty |
| 2 | 55 | 0.44 | 0.83 | 15 | empty |
| 3 | 88 | 0.39 | 0.76 | 12 | empty |
| 4 | 61 | 0.31 | 0.75 | 14 | empty |
Compared structures
- 5THL · Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R · the same entry in another collection · chain A against A, TM-score 1.00
- P54577 · AlphaFold monomer V2.0 prediction for tyrosine--tRNA ligase, cytoplasmic (P54577) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54577
- Elsewhere: RCSB PDB 5THL · PDBe 5THL · UniProt P54577
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