UniProt P54577
Tyrosine--tRNA ligase, cytoplasmic (P54577)
Tyrosine--tRNA ligase, cytoplasmic (UniProt P54577): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54577
- Protein
- Tyrosine--tRNA ligase, cytoplasmic
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 1 record with a druggable one
Structures
14 records of P54577 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1N3L | Crystal structure of a human aminoacyl-tRNA synthetase cytokine | x-ray diffraction | A | — | — |
| 1N3L | Crystal structure of a human aminoacyl-tRNA synthetase cytokine | x-ray diffraction | A | — | — |
| 1NTG | Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase | x-ray diffraction | A, B, C, D | — | — |
| 1NTG | Crystal structure of the emap II-like cytokine released from human tyrosyl-tRNA synthetase | x-ray diffraction | A, B, C, D | — | — |
| 1Q11 | Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol | x-ray diffraction | A | — | — |
| 1Q11 | Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol | x-ray diffraction | A | — | — |
| 4Q93 | Crystal structure of resveratrol bound human tyrosyl tRNA synthetase | x-ray diffraction | A | — | — |
| 4Q93 | Crystal structure of resveratrol bound human tyrosyl tRNA synthetase | x-ray diffraction | A | — | — |
| 4QBT | Crystal structure of tyrosine bound human tyrosyl tRNA synthetase | x-ray diffraction | A | — | — |
| 4QBT | Crystal structure of tyrosine bound human tyrosyl tRNA synthetase | x-ray diffraction | A | — | — |
| 5THH | Crystal structure of a human tyrosyl-tRNA synthetase mutant | x-ray diffraction | A | — | — |
| 5THL | Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R | x-ray diffraction | A | — | — |
| 7ROU | Structure of human tyrosyl tRNA synthetase in complex with ML901-tyr | x-ray diffraction | A | 66I, SO4 | — |
| P54577 | AlphaFold monomer V2.0 prediction for tyrosine--tRNA ligase, cytoplasmic (P54577) | predicted | A | — | 7 (best 0.74) |
Ligands
Experiment against prediction
- 7ROU chain A against the predicted model P54577: TM-score 0.99, RMSD 0.83 Å
- 5THH chain A against the predicted model P54577: TM-score 0.98, RMSD 0.80 Å
- 1Q11 chain A against the predicted model P54577: TM-score 0.98, RMSD 0.81 Å
- 1Q11 chain A against the predicted model P54577: TM-score 0.98, RMSD 0.81 Å
- 4QBT chain A against the predicted model P54577: TM-score 0.98, RMSD 0.88 Å
- 4QBT chain A against the predicted model P54577: TM-score 0.98, RMSD 0.88 Å
- 1NTG chain A against the predicted model P54577: TM-score 0.97, RMSD 0.61 Å
- 1NTG chain A against the predicted model P54577: TM-score 0.97, RMSD 0.61 Å
- 4Q93 chain A against the predicted model P54577: TM-score 0.96, RMSD 1.48 Å
- 4Q93 chain A against the predicted model P54577: TM-score 0.96, RMSD 1.48 Å
Elsewhere
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