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Ligand · TYE

TYE · 4-[(2S)-2-amino-3-hydroxypropyl]phenol

TYE, 4-[(2S)-2-amino-3-hydroxypropyl]phenol (C9 H13 N O2, 167.2 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
TYE
Formula
C9 H13 N O2
Class
ligand
Structures
12
PDB entries
6

Binding sites

TYE in 12 structures; the first of them:

  • 1H3E · Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with wild-type tRNAtyr(GUA)… · TYE A1434 · binds LYS41, GLY43, ALA44, ASP45, ILE75, THR80, ASP85, ASN128 and 6 more
  • 1H3F · Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with tyrosinol · TYE A1433 · binds LYS41, GLY43, ALA44, ASP45, ILE75, ASN128, GLN179, ASP182 and 3 more
  • 1Q11 · Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol · TYE A401 · binds TYR39, GLY41, THR42, ALA43, LEU72, ALA74, HIS77, VAL152 and 6 more
  • 2J5B · Structure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed… · TYE A1336 · binds TYR34, GLY36, PHE37, GLU38, TYR68, ALA70, TYR161, GLN165 and 3 more
  • 3P0I · Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form · TYE A701 · binds TYR36, GLY38, PHE39, GLU40, TRP70, ALA72, PHE75, ILE148 and 5 more
  • 3P0J · Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, triclinic crystal… · TYE A701 · binds TYR36, GLY38, PHE39, GLU40, TRP70, ALA72, GLN167, ASP170 and 2 more
  • 1H3E · Tyrosyl-tRNA synthetase from thermus thermophilus complexed with wild- type TRNATYR(GUA)… · TYE A1434 · binds LYS41, GLY43, ALA44, ASP45, ILE75, THR80, ASP85, ASN128 and 6 more
  • 1H3F · Tyrosyl-tRNA synthetase from thermus thermophilus complexed with tyrosinol · TYE A1433 · binds LYS41, GLY43, ALA44, ASP45, ILE75, ASN128, GLN179, ASP182 and 3 more
  • 1Q11 · Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol · TYE A401 · binds TYR39, GLY41, THR42, ALA43, LEU72, ALA74, HIS77, VAL152 and 6 more
  • 2J5B · Structure of the tyrosyl tRNA synthetase from acanthamoeba polyphaga mimivirus complexed… · TYE A1336 · binds TYR34, GLY36, PHE37, GLU38, TYR68, ALA70, TYR161, GLN165 and 3 more
  • 3P0I · Leishmania major tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form · TYE A701 · binds TYR36, GLY38, PHE39, GLU40, TRP70, ALA72, PHE75, ILE148 and 5 more
  • 3P0J · Leishmania major tyrosyl-tRNA synthetase in complex with tyrosinol, triclinic crystal… · TYE A701 · binds TYR36, GLY38, PHE39, GLU40, TRP70, ALA72, GLN167, ASP170 and 2 more

Residues it binds most

GLN 24, TYR 20, ASP 24, ALA 24, GLY 24, PHE 16, GLU 22, LEU 18, ILE 16, ASN 6 (residue and the binding sites it lines).

Found with

  • ATP · Adenosine-5'-triphosphate
  • K · Potassium ion
  • NA · Sodium ion
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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