MolNFT v1 · #455369 · protein
AlphaFold monomer V2.0 prediction for tyrosine--tRNA ligase, cytoplasmic (P54577)
P54577: “AlphaFold monomer V2.0 prediction for tyrosine--tRNA ligase, cytoplasmic (P54577)”. 7 pockets (best druggability 0.74). MolNFT v1 #455369 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P54577
- Type
- protein
- Length
- 528 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x69fc39B8A7390Db29e02023019DFaf30fc148a69
- Molecule
- Tyrosine--tRNA ligase, cytoplasmic
- UniProt
- P54577
- Pockets
- 7 · best druggability 0.74
Structure
1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine--tRNA ligase, cytoplasmic | protein | 528 | 39% helix, 21% strand | P54577 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 805 | 0.74 | 0.79 | 65 | empty |
| 2 | 190 | 0.49 | 0.76 | 29 | empty |
| 3 | 113 | 0.44 | 0.77 | 15 | empty |
| 4 | 52 | 0.43 | 0.83 | 16 | empty |
| 5 | 74 | 0.32 | 0.74 | 16 | empty |
Compared structures
- 7ROU · Structure of human tyrosyl tRNA synthetase in complex with ML901-tyr · an experimental structure of the same protein · chain A against A, TM-score 0.63
- 5THH · Crystal structure of a human tyrosyl-tRNA synthetase mutant · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1Q11 · Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1Q11 · Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 4QBT · Crystal structure of tyrosine bound human tyrosyl tRNA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 4QBT · Crystal structure of tyrosine bound human tyrosyl tRNA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 1N3L · Crystal structure of a human aminoacyl-tRNA synthetase cytokine · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 1N3L · Crystal structure of a human aminoacyl-tRNA synthetase cytokine · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 4Q93 · Crystal structure of resveratrol bound human tyrosyl tRNA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 4Q93 · Crystal structure of resveratrol bound human tyrosyl tRNA synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 5THL · Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 1NTG · Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54577
- Elsewhere: UniProt P54577 · AlphaFold DB P54577
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