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Apo PDZ domain from rat SHANK3

Analyse Apo PDZ domain from rat SHANK3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5OVA
Type: protein
Length: 183 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SH3 and multiple ankyrin repeat domains protein 3
UniProt: Q9JLU4
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SH3 and multiple ankyrin repeat domains protein 3	protein	92	15% helix, 35% strand	Q9JLU4
B	SH3 and multiple ankyrin repeat domains protein 3	protein	91	15% helix, 33% strand	Q9JLU4

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	523	0.64	0.76	35	empty

Interfaces

1 interface between chains.

A–B · 495 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5OVA · Apo PDZ domain from rat Shank3 · the same entry in another collection · chain A against A, TM-score 1.00
Q9JLU4 · AlphaFold monomer V2.0 prediction for SH3 and multiple ankyrin repeat domains protein 3… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JLU4
Elsewhere: RCSB PDB 5OVA · PDBe 5OVA · UniProt Q9JLU4

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