Research workbench
Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.
Analyse Discovery of small molecules binding to KRAS via high affinity antibody… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5OCO
- Type
- protein
- Length
- 1,034 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P01116
- Ligands
- GNP, 9RK, MG
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, E | — | protein | 173 | — | P01116 |
| A, C, D, F | — | protein | 172 | — | P01116 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 6 copies · chains B, A, C, D, E, F
- 9RK · ~{N}-[[(3~{R})-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]furan-2-carboxamide · ligand · 5 copies · chains B, C, D, E, F
- MG · Magnesium ion · metal · 6 copies · chains B, A, C, D, E, F
- CIT · Citric acid · additive · 3 copies · chains A, D
- PEG · Di(hydroxyethyl)ether · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Elsewhere: RCSB PDB 5OCO · PDBe 5OCO · UniProt P01116
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