Crystal structure of thermostabilised full-length glp-1R in complex with a truncated peptide agonist at 3.7 a resolution

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• SOG · octyl 1-thio-beta-D-glucopyranoside · ligand · 3 copies · chains A
• 9DK · 3-[2-(1~{H}-imidazol-4-yl)ethylamino]-2,2-dimethyl-3-oxidanylidene-propanoic acid · ligand · chains A, B
• 9DQ · (2~{S})-2-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl) propanoic acid · ligand · chains A, B
• 9DT · (2~{S})-2-azanyl-3-(2-fluorophenyl)-2-methyl-propanoic acid · ligand · chains A, B
• 9DW · (2~{S})-2-azanyl-3-[4-(2-ethyl-4-methoxy-phenyl) phenyl]propanoic acid · ligand · chains A, B
• 9DZ · (2~{S})-2-azanyl-5-(3,5-dimethylphenyl)pentanamide · ligand · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5NX2 · Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated… · the same entry in another collection · chain A against A, TM-score 1.00
• P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P43220
• Elsewhere: RCSB PDB 5NX2 · PDBe 5NX2 · UniProt P43220