Research workbench
Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of enzyme in its ketimine form with the substrate L-isoleucine
Analyse Human branched chain amino acid aminotransferase (mitochondrial): three… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KT8
- Type
- protein
- Length
- 725 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Branched-chain amino acid aminotransferase, mitochondrial
- EC
- 2.6.1.42
- UniProt
- O15382
- Ligands
- ILP
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Branched-chain amino acid aminotransferase, mitochondrial (EC 2.6.1.42) | protein | 360 | 25% helix, 31% strand | O15382 |
| B | Branched-chain amino acid aminotransferase, mitochondrial (EC 2.6.1.42) | protein | 365 | 25% helix, 29% strand | O15382 |
Ligands and binding sites
- ILP · N-[O-phosphono-pyridoxyl]-isoleucine · ligand · 2 copies · chains A, B
- ACY · Acetic acid · additive · 6 copies · chains A, B
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.74 | 0.83 | 48 | ILP |
| 2 | 475 | 0.74 | 0.83 | 52 | ILP |
| 3 | 145 | 0.73 | 0.92 | 47 | GOL |
| 4 | 215 | 0.64 | 0.83 | 27 | empty |
| 5 | 208 | 0.59 | 0.80 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2404 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 1KT8 · Human branched chain amino acid aminotransferase (mitochondrial): three dimensional… · the same entry in another collection · chain A against A, TM-score 1.00
- O15382 · AlphaFold monomer V2.0 prediction for branched-chain-amino-acid aminotransferase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15382
- Elsewhere: RCSB PDB 1KT8 · PDBe 1KT8 · UniProt O15382
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